DNA – SyntMWG – Biotech; Labautomation,hesis, DNA – Sequencing, Bioinformation – Partner der Wahl für synthesis with siMAX technology

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).

Leave a Comment / Circulating Tumor DNA Using Tagged Targeted Deep Sequencing to Assess Minimal Residual Disease in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy., Genetic diversity, population structure, and relationships of apricot (Prunus) based on restriction site-associated DNA sequencing. / By Max

Developing effective therapies against chronic wound healing deficiencies is a global priority. Thus we evaluated the safety of two different doses of topically administered autologous APOSEC, the secretome of apoptotic peripheral blood mononuclear cells (PBMCs), in healthy male volunteers with artificial dermal wounds. Ten healthy men were enrolled in a single-center, randomized, double-blinded, placebo-controlled phase …

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I). Read More »

Towards clinically friendly optoretinography (ORG) using 100 kHz swept-source OCT without adaptive optics (AO)

Optoretinography measures the stimulus-evoked response of the photoreceptors using light. Current systems use adaptive optics (AO) to obtain cellular-level resolution and fast volume acquisitions, to be able to monitor a single cone’s response with sufficient sampling over time. The systems are complex to operate and therefore are not ideal in the clinical setting, where ease-of-use …

Towards clinically friendly optoretinography (ORG) using 100 kHz swept-source OCT without adaptive optics (AO) Read More »

Nocardiosis in the Illawarra-Shoalhaven region from 2010 to 2019.

There is a need for simple microbiology diagnostics to enable antimicrobial resistance surveillance in low- and middle-income countries. To investigate the field utility of InTray COLOREX plates for urine culture and ESBL detection. Clinical urine samples from Mahosot Hospital, Vientiane, Lao PDR were inoculated onto chromogenic media and InTray COLOREX Screen plates between June and August 2020. …

Nocardiosis in the Illawarra-Shoalhaven region from 2010 to 2019. Read More »

Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles.

Recent studies on extracellular RNA raised awareness that extracellular vesicles (EVs) isolated from cultured cells may co-purify RNAs derived from media supplements such as fetal bovine serum (FBS) confounding EV-associated RNA. Defined culture media supplemented with a range of nutrient components provide an alternative to FBS addition and allow EV-collection under full medium conditions avoiding …

Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles. Read More »

Circulating Tumor DNA Using Tagged Targeted Deep Sequencing to Assess Minimal Residual Disease in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.

Leave a Comment / Circulating Tumor DNA Using Tagged Targeted Deep Sequencing to Assess Minimal Residual Disease in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy. / By Max

In breast cancer patients undergoing neoadjuvant chemotherapy before surgery, there is an unmet need for non-invasive biomarkers predictive of response. Analysis of DNA circulating tumor (ctDNA) in particular has been the object of several reports, but some of them have studied the application of targeted sequencing marked in (tTDS) for clinical practice and performance compared …

Circulating Tumor DNA Using Tagged Targeted Deep Sequencing to Assess Minimal Residual Disease in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy. Read More »

Genetic diversity, population structure, and relationships of apricot (Prunus) based on restriction site-associated DNA sequencing.

Leave a Comment / Genetic diversity, population structure, and relationships of apricot (Prunus) based on restriction site-associated DNA sequencing. / By Max

Single-nucleotide polymorphisms (SNPs) are the most abundant form of genomic polymorphism and is widely used in population genetics research. Here, the high-throughput sequencing is used to test the genome-level diversity, population structure, and relationships apricots, which are important for the conservation of germplasm and molecular breeding. Restriction-site associated DNA sequencing (RAD-seq) adopted to sequence 168 …

Genetic diversity, population structure, and relationships of apricot (Prunus) based on restriction site-associated DNA sequencing. Read More »

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Leave a Comment / Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer. / By Max

Neoantigens evolutionary dynamics related tumors carry information on drug sensitivity and resistance to immune checkpoint blockade (ICB). However, the spectrum of somatic mutations are very heterogeneous between patients, making it difficult to track neoantigens by circulating tumor DNA (ctDNA) sequencing using a “one size fits all” commercial gene panel. Thus, individually adjustable panel (ICPs) that …

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer. Read More »