Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

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Neoantigens evolutionary dynamics related tumors carry information on drug sensitivity and resistance to immune checkpoint blockade (ICB). However, the spectrum of somatic mutations are very heterogeneous between patients, making it difficult to track neoantigens by circulating tumor DNA (ctDNA) sequencing using a “one size fits all” commercial gene panel. Thus, individually adjustable panel (ICPs) that is needed to track the evolution of a comprehensive neoantigen during treatment ICB. dominant neoantigens estimated from all data that exome sequencing on tumor tissue that has not been treated.

The panel predicted neoantigens targeting is used to personalize ctDNA sequencing. Analyzing the ten patients with lung cancer non-small cell ICPs dominant neoantigens effective to track the most predictable (80-100%) in a series of peripheral blood samples, and to detect substantially more genes (18-30) of the capacity of the current commercial gene this panel. A decline of more than 50% in the concentration ctDNA after eight weeks of administration ICB associated with progression-free survival benefit. Furthermore, at the individual level, the magnitude of the initial ctDNA response correlated with subsequent changes in tumor burden. CtDNA ICP-based application of sequencing are expected to improve the understanding of the evolution of ICB-driven tumor and to provide personal management strategies that optimize the clinical benefit of immunotherapy.

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.
Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Identify locoregional gastric cancer patients at high risk for recurrence after resection can facilitate early intervention. By detecting the molecular residual disease (MRD), circulating tumor DNA (ctDNA) has been shown to predict postoperative recurrence in some cancers. Here, we aimed to evaluate the detection of MRD by ctDNA and its association with clinical outcomes in resected gastric cancer.

This prospective cohort study enrolled 46 patients with stage I-III gastric cancer who underwent resection with curative intent. Sixty resected tumor samples and 296 samples of plasma obtained for targeted sequencing within and extending ctDNA profiling. CtDNA detection correlated with clinicopathological features and postoperative disease-free (DFS) and overall survival (OS). ctDNA detected in 45% of plasma samples that have not been treated. As far as the primary tumor (T stage) were independently associated with preoperative positive ctDNA (p = 0.006)

WDR20
MBS8564524-01mLAF405L 0.1mL(AF405L)
EUR 565

WDR20
MBS8564524-01mLAF405S 0.1mL(AF405S)
EUR 565

WDR20
MBS8564524-01mLAF610 0.1mL(AF610)
EUR 565

WDR20
MBS8564524-01mLAF635 0.1mL(AF635)
EUR 565

WDR20
MBS8564524-02mL 0.2mL
EUR 345

WDR20 siRNA
20-abx939694
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

WDR20 siRNA
20-abx939695
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

WDR20 Antibody
C47123-100ul 100μl
EUR 217
Description: WDR20 Rabbit Polyclonal Antibody

WDR20 Antibody
C47123-50ul 50μl
EUR 143.5
Description: WDR20 Rabbit Polyclonal Antibody

WDR20 Antibody
DF15922 100ul
EUR 420

WDR20 Antibody
DF15922-100ul 100ul
EUR 168
Description: ELISA(peptide)

WDR20 Antibody
DF15922-200ul 200ul
EUR 210
Description: ELISA(peptide)

WDR20 Antibody
E313028 200ul
EUR 275
Description: Available in various conjugation types.

WDR20 Antibody
MBS9631210-01mL 0.1mL
EUR 260

WDR20 Antibody
MBS9631210-02mL 0.2mL
EUR 305

WDR20 Antibody
MBS9631210-5x02mL 5x0.2mL
EUR 1220

WDR20 Antibody
MBS9633593-1mg 1mg
EUR 375

WDR20 Antibody
MBS9633593-5x1mg 5x1mg
EUR 1545

Wdr20 (untagged) - Rat WD repeat domain 20 (Wdr20)
RN216949 10 µg Ask for price

WDR20 cDNA Clone
MBS1277815-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

WDR20 cDNA Clone
MBS1277815-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

WDR20 cDNA Clone
MBS1271465-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 330

WDR20 cDNA Clone
MBS1271465-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 1430

WDR20 rabbit pAb
E28PN3216 100μl
EUR 255
Description: Available in various conjugation types.

WDR20 rabbit pAb
E44H12100 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

WDR20 rabbit pAb
UB-GEN-7893 100 ul
EUR 200

Mouse WDR20 siRNA
abx939694-150g 150 µg
EUR 450

Mouse WDR20 siRNA
abx939694-300g 300 µg
EUR 612.5

Human WDR20 siRNA
abx939695-150g 150 µg
EUR 450

Human WDR20 siRNA
abx939695-300g 300 µg
EUR 612.5

WDR20 siRNA (Human)
MBS8217265-15nmol 15nmol
EUR 405

WDR20 siRNA (Human)
MBS8217265-30nmol 30nmol
EUR 565

WDR20 siRNA (Human)
MBS8217265-5x30nmol 5x30nmol
EUR 2450

WDR20 siRNA (Mouse)
MBS8230463-15nmol 15nmol
EUR 405

WDR20 siRNA (Mouse)
MBS8230463-30nmol 30nmol
EUR 565

WDR20 siRNA (Mouse)
MBS8230463-5x30nmol 5x30nmol
EUR 2450

anti- WDR20 antibody
FNab09486 100µg
EUR 702
Description: Antibody raised against WDR20

WDR20 cloning plasmid
CSB-CL823451HU1-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the WDR20 gene.

WDR20 cloning plasmid
CSB-CL823451HU2-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the WDR20 gene.

Wdr20 (myc-DDK-tagged) - Rat WD repeat domain 20 (Wdr20)
RR216949 10 µg Ask for price

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR)
MBS6006270-02mL 0.2(mL
EUR 695

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR)
MBS6006270-5x02mL 5x0.2mL
EUR 2975

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (AP)
MBS6363115-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (AP)
MBS6363115-5x02mL 5x0.2mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (PE)
MBS6363125-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (PE)
MBS6363125-5x02mL 5x0.2mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (APC)
MBS6363116-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (APC)
MBS6363116-5x02mL 5x0.2mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (FITC)
MBS6363118-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (FITC)
MBS6363118-5x02mL 5x0.2mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (Biotin)
MBS6363117-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (Biotin)
MBS6363117-5x02mL 5x0.2mL
EUR 4250

WDR20 ELISA KIT|Human
EF004268 96 Tests
EUR 826.8

WDR20 (untagged)-Human WD repeat domain 20 (WDR20), transcript variant 3
SC307269 10 µg Ask for price

WDR20 (untagged)-Human WD repeat domain 20 (WDR20), transcript variant 1
SC314097 10 µg Ask for price

WDR20 (untagged)-Human WD repeat domain 20 (WDR20), transcript variant 2
SC120733 10 µg Ask for price

WDR20 Antibody (N-term)
E45R31591G-1 100 ul
EUR 395

WDR20 Antibody (N-term)
E45R31591G-4 50 ul
EUR 295

WDR20 Antibody (N-term)
MBS9208088-008mL 0.08mL
EUR 210

WDR20 Antibody (N-term)
MBS9208088-04mL 0.4mL
EUR 430

WDR20 Antibody (N-term)
MBS9208088-5x04mL 5x0.4mL
EUR 1910

Mouse WDR20 shRNA Plasmid
20-abx977330
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human WDR20 shRNA Plasmid
20-abx964083
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human WDR20 Protein Lysate
MBS8429799-INQUIRE INQUIRE Ask for price

Recombinant Human WDR20 Protein
E30P03645A 50 ug
EUR 295

WDR20 Recombinant Protein (Human)
RP034579 100 ug Ask for price

WDR20 Recombinant Protein (Human)
RP034582 100 ug Ask for price

WDR20 Rabbit Polyclonal Antibody
BT-AP05484-100ul 100ul Ask for price
Description: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.

WDR20 Rabbit Polyclonal Antibody
BT-AP05484-20ul 20ul Ask for price
Description: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.

WDR20 Rabbit Polyclonal Antibody
BT-AP05484-50ul 50ul Ask for price
Description: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.

WDR20 Rabbit Polyclonal Antibody
JOT-AP05484-100ul 100ul
EUR 220

WDR20 Rabbit Polyclonal Antibody
JOT-AP05484-50ul 50ul
EUR 144

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 405)
MBS6363120-01mL 0.1mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 405)
MBS6363120-5x01mL 5x0.1mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 490)
MBS6363121-01mL 0.1mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 490)
MBS6363121-5x01mL 5x0.1mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 550)
MBS6363122-01mL 0.1mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 550)
MBS6363122-5x01mL 5x0.1mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 650)
MBS6363123-01mL 0.1mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 650)
MBS6363123-5x01mL 5x0.1mL
EUR 4250

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 750)
MBS6363124-01mL 0.1mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (MaxLight 750)
MBS6363124-5x01mL 5x0.1mL
EUR 4250

WDR20 (GFP-tagged) - Human WD repeat domain 20 (WDR20), transcript variant 1
RG218826 10 µg Ask for price

WDR20 (GFP-tagged) - Human WD repeat domain 20 (WDR20), transcript variant 3
RG224786 10 µg Ask for price

WDR20 (GFP-tagged) - Human WD repeat domain 20 (WDR20), transcript variant 2
RG206075 10 µg Ask for price

WDR20 (untagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 4
SC331797 10 µg Ask for price

WDR20 (untagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 5
SC331798 10 µg Ask for price

WDR20 (untagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 6
SC331799 10 µg Ask for price

WDR20 (untagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 7
SC331800 10 µg Ask for price

WDR20 (untagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 8
SC331801 10 µg Ask for price

WDR20 (NM_144574) Human Recombinant Protein
E45H39057M5 20 ug
EUR 785.42

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (Azide free) (HRP)
MBS6363119-02mL 0.2mL
EUR 980

WDR20, NT (WDR20, WD repeat-containing protein 20, Protein DMR) (Azide free) (HRP)
MBS6363119-5x02mL 5x0.2mL
EUR 4250

WDR20 (N-term) Rabbit pAb
E2613623 100ul
EUR 225
Description: Available in various conjugation types.

WDR20 (N-Term) Rabbit pAb
MBS8553019-01mL 0.1mL
EUR 305

WDR20 (N-Term) Rabbit pAb
MBS8553019-01mLAF405L 0.1mL(AF405L)
EUR 565

WDR20 (N-Term) Rabbit pAb
MBS8553019-01mLAF405S 0.1mL(AF405S)
EUR 565

WDR20 (N-Term) Rabbit pAb
MBS8553019-01mLAF610 0.1mL(AF610)
EUR 565

WDR20 (N-Term) Rabbit pAb
MBS8553019-01mLAF635 0.1mL(AF635)
EUR 565

WDR20 (Myc-DDK-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 1
RC218826 10 µg Ask for price

WDR20 (Myc-DDK-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 3
RC224786 10 µg Ask for price

WDR20 (Myc-DDK-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 2
RC206075 10 µg Ask for price

WDR20 (GFP-tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 4
RG233245 10 µg Ask for price

WDR20 (GFP-tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 5
RG233407 10 µg Ask for price

WDR20 (GFP-tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 6
RG234341 10 µg Ask for price

WDR20 (GFP-tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 8
RG234486 10 µg Ask for price

WDR20 (GFP-tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 7
RG234525 10 µg Ask for price

WDR20 ORF Vector (Human) (pORF)
ORF011527 1.0 ug DNA
EUR 114

WDR20 ORF Vector (Human) (pORF)
ORF011528 1.0 ug DNA
EUR 114

Human WDR20 knockout cell line
ABC-KH16904 1 vial Ask for price
Description: Human WDR20 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human WDR20 knockdown cell line
ABC-KD16904 1 vial Ask for price
Description: Human WDR20 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human WDR20 Protein Lysate 20ug
IHUWDR20PLLY20UG each
EUR 361
Description: Human WDR20 Protein Lysate 20ug

Recombinant Human WDR20, His-tagged
WDR20-3710H 25ug
EUR 255.2
Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.

OCOA04609-20UG - WDR20 Protein Lysate
OCOA04609-20UG 20ug
EUR 269

OCOA04610-20UG - WDR20 Protein Lysate
OCOA04610-20UG 20ug
EUR 269

OCOA06279-20UG - WDR20 Protein Lysate
OCOA06279-20UG 20ug
EUR 169

WDR20 Over-expression Lysate Product
GWB-BBAB80 0.1 mg Ask for price

WDR20 (Myc-DDK tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 8
RC234486 10 µg Ask for price

WDR20 (Myc-DDK tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 7
RC234525 10 µg Ask for price

WDR20 (Myc-DDK tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 4
RC233245 10 µg Ask for price

WDR20 (Myc-DDK tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 5
RC233407 10 µg Ask for price

WDR20 (Myc-DDK tagged) - Homo sapiens WD repeat domain 20 (WDR20), transcript variant 6
RC234341 10 µg Ask for price

WDR20 (NM_181308) Human Over-expression Lysate
E45H15684-2 each
EUR 395

WDR20 (NM_181291) Human Over-expression Lysate
E45H15685-2 each
EUR 395

WDR20 (NM_144574) Human Over-expression Lysate
E45H14017-2 each
EUR 395

WDR20 (NM_144574) Human Over-expression Lysate
LS091833 100ug
EUR 628
Description: Transient overexpression lysate of WD repeat domain 20 (WDR20), transcript variant 2

WDR20 sgRNA CRISPR Lentivector set (Human)
K2629701 3 x 1.0 ug
EUR 406.8

WDR20 Antibody (N-term) Blocking Peptide
MBS9222891-INQUIRE INQUIRE Ask for price

WDR20 (N-term) Rabbit Polyclonal Antibody
E10G31875 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lenti-ORF clone of WDR20 (mGFP-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 1
RC218826L4 10 µg Ask for price

Lenti-ORF clone of WDR20 (mGFP-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 3
RC224786L4 10 µg Ask for price

WDR20 3'UTR GFP Stable Cell Line
TU078406 1.0 ml
EUR 1825.2

Lenti-ORF clone of WDR20 (Myc-DDK-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 1
RC218826L3 10 µg Ask for price

Lenti-ORF clone of WDR20 (Myc-DDK-tagged)-Human WD repeat domain 20 (WDR20), transcript variant 3
RC224786L3 10 µg Ask for price

WDR20 Protein Vector (Human) (pPM-C-HA)
PV046107 500 ng
EUR 394.8

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