Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Neoantigens evolutionary dynamics related tumors carry information on drug sensitivity and resistance to immune checkpoint blockade (ICB). However, the spectrum of somatic mutations are very heterogeneous between patients, making it difficult to track neoantigens by circulating tumor DNA (ctDNA) sequencing using a “one size fits all” commercial gene panel. Thus, individually adjustable panel (ICPs) that is needed to track the evolution of a comprehensive neoantigen during treatment ICB. dominant neoantigens estimated from all data that exome sequencing on tumor tissue that has not been treated.

The panel predicted neoantigens targeting is used to personalize ctDNA sequencing. Analyzing the ten patients with lung cancer non-small cell ICPs dominant neoantigens effective to track the most predictable (80-100%) in a series of peripheral blood samples, and to detect substantially more genes (18-30) of the capacity of the current commercial gene this panel. A decline of more than 50% in the concentration ctDNA after eight weeks of administration ICB associated with progression-free survival benefit. Furthermore, at the individual level, the magnitude of the initial ctDNA response correlated with subsequent changes in tumor burden. CtDNA ICP-based application of sequencing are expected to improve the understanding of the evolution of ICB-driven tumor and to provide personal management strategies that optimize the clinical benefit of immunotherapy.

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.
Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non-Small Cell Lung Cancer.

Identify locoregional gastric cancer patients at high risk for recurrence after resection can facilitate early intervention. By detecting the molecular residual disease (MRD), circulating tumor DNA (ctDNA) has been shown to predict postoperative recurrence in some cancers. Here, we aimed to evaluate the detection of MRD by ctDNA and its association with clinical outcomes in resected gastric cancer.

This prospective cohort study enrolled 46 patients with stage I-III gastric cancer who underwent resection with curative intent. Sixty resected tumor samples and 296 samples of plasma obtained for targeted sequencing within and extending ctDNA profiling. CtDNA detection correlated with clinicopathological features and postoperative disease-free (DFS) and overall survival (OS). ctDNA detected in 45% of plasma samples that have not been treated. As far as the primary tumor (T stage) were independently associated with preoperative positive ctDNA (p = 0.006)

WDR20 Antibody

DF15922-200ul 200ul
EUR 350

WDR20 Antibody

E313028 200ul
EUR 275
Description: Available in various conjugation types.

WDR20 rabbit pAb

E28PN3216 100μl
EUR 255
Description: Available in various conjugation types.

anti- WDR20 antibody

FNab09486 100µg
EUR 702
Description: Antibody raised against WDR20

WDR20 cloning plasmid

CSB-CL823451HU1-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the WDR20 gene.

WDR20 cloning plasmid

CSB-CL823451HU2-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the WDR20 gene.

WDR20 ELISA KIT|Human

EF004268 96 Tests
EUR 826.8

Mouse WDR20 shRNA Plasmid

20-abx977330
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human WDR20 shRNA Plasmid

20-abx964083
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

WDR20 Recombinant Protein (Human)

RP034579 100 ug Ask for price

WDR20 Recombinant Protein (Human)

RP034582 100 ug Ask for price

WDR20 (N-term) Rabbit pAb

E2613623 100ul
EUR 225
Description: Available in various conjugation types.

WDR20 ORF Vector (Human) (pORF)

ORF011527 1.0 ug DNA
EUR 114

WDR20 ORF Vector (Human) (pORF)

ORF011528 1.0 ug DNA
EUR 114

Human WDR20 Protein Lysate 20ug

IHUWDR20PLLY20UG each
EUR 361
Description: Human WDR20 Protein Lysate 20ug

WDR20 sgRNA CRISPR Lentivector set (Human)

K2629701 3 x 1.0 ug
EUR 406.8

WDR20 3'UTR GFP Stable Cell Line

TU078406 1.0 ml
EUR 1825.2

WDR20 Protein Vector (Human) (pPM-C-HA)

PV046107 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPM-C-HA)

PV046111 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPB-C-His)

PV046105 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPB-N-His)

PV046106 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPM-C-His)

PV046108 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPB-C-His)

PV046109 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPB-N-His)

PV046110 500 ng
EUR 394.8

WDR20 Protein Vector (Human) (pPM-C-His)

PV046112 500 ng
EUR 394.8

WDR20 3'UTR Luciferase Stable Cell Line

TU028406 1.0 ml
EUR 1825.2

WDR20 sgRNA CRISPR Lentivector (Human) (Target 1)

K2629702 1.0 ug DNA
EUR 184.8

WDR20 sgRNA CRISPR Lentivector (Human) (Target 2)

K2629703 1.0 ug DNA
EUR 184.8

WDR20 sgRNA CRISPR Lentivector (Human) (Target 3)

K2629704 1.0 ug DNA
EUR 184.8

WD Repeat-Containing Protein 20 (WDR20) Antibody

abx239486-100ug 100 ug
EUR 661.2

WD Repeat-Containing Protein 20 (WDR20) Antibody

abx029810-400ul 400 ul
EUR 627.6

WD Repeat-Containing Protein 20 (WDR20) Antibody

abx029810-80l 80 µl
EUR 343.2

WDR20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV716763 1.0 ug DNA
EUR 379.2

WDR20 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV716767 1.0 ug DNA
EUR 379.2

WDR20 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV716768 1.0 ug DNA
EUR 379.2

Mouse WD repeat- containing protein 20, Wdr20 ELISA KIT

ELI-51469m 96 Tests
EUR 1038

Human WD repeat- containing protein 20, WDR20 ELISA KIT

ELI-16960h 96 Tests
EUR 988.8

Human WD repeat-containing protein 20 (WDR20) ELISA Kit

abx384285-96tests 96 tests
EUR 1093.2

WDR20 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K2629705 3 x 1.0 ug
EUR 451.2

WDR20 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K2629706 1.0 ug DNA
EUR 200.4

WDR20 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K2629707 1.0 ug DNA
EUR 200.4

WDR20 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K2629708 1.0 ug DNA
EUR 200.4

WDR20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV716764 1.0 ug DNA
EUR 379.2

WDR20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV716765 1.0 ug DNA
EUR 448.8

WDR20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV716766 1.0 ug DNA
EUR 448.8

anti-WDR20

YF-PA21726 50 ul
EUR 435.6
Description: Mouse polyclonal to WDR20

anti-WDR20

YF-PA21727 50 ug
EUR 435.6
Description: Mouse polyclonal to WDR20

anti-WDR20

YF-PA21728 100 ul
EUR 483.6
Description: Rabbit polyclonal to WDR20

Anti-WDR20 antibody

PAab09486 100 ug
EUR 494.4

Anti-WDR20 (2A6)

YF-MA11715 100 ug
EUR 435.6
Description: Mouse monoclonal to WDR20

Anti-WDR20 (1D10)

YF-MA19652 100 ug
EUR 435.6
Description: Mouse monoclonal to WDR20

WDR5-0103

HY-19347 100mg
EUR 1135.2

Wdr18/ Rat Wdr18 ELISA Kit

ELI-51468r 96 Tests
EUR 1063.2

Wdr44/ Rat Wdr44 ELISA Kit

ELI-40511r 96 Tests
EUR 1063.2

Wdr61/ Rat Wdr61 ELISA Kit

ELI-35296r 96 Tests
EUR 1063.2

Wdr83/ Rat Wdr83 ELISA Kit

ELI-35298r 96 Tests
EUR 1063.2

Wdr55/ Rat Wdr55 ELISA Kit

ELI-14864r 96 Tests
EUR 1063.2

Wdr70/ Rat Wdr70 ELISA Kit

ELI-17501r 96 Tests
EUR 1063.2

Wdr69/ Rat Wdr69 ELISA Kit

ELI-17513r 96 Tests
EUR 1063.2

Wdr89/ Rat Wdr89 ELISA Kit

ELI-17520r 96 Tests
EUR 1063.2

Wdr77/ Rat Wdr77 ELISA Kit

ELI-13009r 96 Tests
EUR 1063.2

Wdr78/ Rat Wdr78 ELISA Kit

ELI-16965r 96 Tests
EUR 1063.2

WDR19/IFT144 (WDR19) Antibody

abx239485-100ug 100 ug
EUR 610.8

Human WDR19/IFT144 (WDR19) ELISA Kit

abx392181-96tests 96 tests
EUR 1093.2

WDR5 0103

B4949-10 10 mg
EUR 266.4

WDR5 0103

B4949-5.1 10 mM (in 1mL DMSO)
EUR 150

WDR5 0103

B4949-50 50 mg
EUR 931.2

Rat Ribosome biogenesis protein WDR12, Wdr12 ELISA KIT

ELI-51495r 96 Tests
EUR 1063.2

Mouse Ribosome biogenesis protein WDR12, Wdr12 ELISA KIT

ELI-51073m 96 Tests
EUR 1038

Human Ribosome biogenesis protein WDR12, WDR12 ELISA KIT

ELI-44485h 96 Tests
EUR 988.8

Human Ribosome biogenesis protein WDR12(WDR12) ELISA kit

QY-E05324 96T
EUR 433.2

Human Ribosome biogenesis protein WDR12(WDR12) ELISA Kit

NSL1355Hu 96 wells
EUR 468

WDR26

E8ER1918-63 100ul
EUR 275
Description: Available in various conjugation types.

Bovine Ribosome biogenesis protein WDR12, WDR12 ELISA KIT

ELI-14860b 96 Tests
EUR 1113.6

Canine Ribosome biogenesis protein WDR12(WDR12) ELISA Kit

NSL1246Ca 1341 wells
EUR 528

Bovine Ribosome biogenesis protein WDR12(WDR12) ELISA Kit

NSL1216Bo 96 T
EUR 528

Wdr7/ Rat Wdr7 ELISA Kit

ELI-51504r 96 Tests
EUR 1063.2

Wdr5/ Rat Wdr5 ELISA Kit

ELI-28268r 96 Tests
EUR 1063.2

Wdr1/ Rat Wdr1 ELISA Kit

ELI-35289r 96 Tests
EUR 1063.2

Wdr6/ Rat Wdr6 ELISA Kit

ELI-22510r 96 Tests
EUR 1063.2

Wdr5b/ Rat Wdr5b ELISA Kit

ELI-51075r 96 Tests
EUR 1063.2

WDR11 siRNA

20-abx939679
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR11 siRNA

20-abx939680
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR12 siRNA

20-abx939681
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR12 siRNA

20-abx939682
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR13 siRNA

20-abx939683
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR13 siRNA

20-abx939684
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR16 siRNA

20-abx939685
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR16 siRNA

20-abx939686
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR17 siRNA

20-abx939687
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR18 siRNA

20-abx939688
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR18 siRNA

20-abx939689
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR19 siRNA

20-abx939690
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR19 siRNA

20-abx939691
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR24 siRNA

20-abx939696
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR24 siRNA

20-abx939697
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR25 siRNA

20-abx939698
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR25 siRNA

20-abx939699
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR26 siRNA

20-abx939700
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR26 siRNA

20-abx939701
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR27 siRNA

20-abx939702
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR27 siRNA

20-abx939703
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR31 siRNA

20-abx939704
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR31 siRNA

20-abx939705
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR33 siRNA

20-abx939706
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR33 siRNA

20-abx939707
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR34 siRNA

20-abx939708
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR34 siRNA

20-abx939709
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR35 siRNA

20-abx939710
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR35 siRNA

20-abx939711
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR36 siRNA

20-abx939712
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR37 siRNA

20-abx939713
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR37 siRNA

20-abx939714
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR38 siRNA

20-abx939715
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR38 siRNA

20-abx939716
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR41 siRNA

20-abx939719
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR41 siRNA

20-abx939720
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR43 siRNA

20-abx939721
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR43 siRNA

20-abx939722
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR44 siRNA

20-abx939723
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR44 siRNA

20-abx939724
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR45 siRNA

20-abx939727
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR45 siRNA

20-abx939728
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR46 siRNA

20-abx939729
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR46 siRNA

20-abx939730
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR47 siRNA

20-abx939731
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR47 siRNA

20-abx939732
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR48 siRNA

20-abx939733
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR48 siRNA

20-abx939734
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR49 siRNA

20-abx939735
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR52 siRNA

20-abx939738
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR53 siRNA

20-abx939739
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

WDR53 siRNA

20-abx939740
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

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